Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and promote survival
Activating anaplastic lymphoma kinase (ALK) receptor tyrosine kinase (RTK) mutations occur in pediatric neuroblastoma and are associated with poor prognosis. To study ALK-activating mutations in a genetically controllable system, we employed CRIPSR/Cas9, incorporating orthologs of the human oncogeni...
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| Main Authors: | , , , , , , , |
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| Format: | Book |
| Published: |
The Company of Biologists,
2022-08-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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