Computer-aided design and synthesis of 3-carbonyl-5-phenyl-1H-pyrazole as highly selective and potent BRAFV600E and CRAF inhibitor

BRAF belongs to the upstream portion of the MAPK pathway, which is involved in cell proliferation and survival. When mutations occur in BRAF, downstream MEK and ERK are phosphorylated irrespective of RAS, resulting in melanoma-like cancer. Over the years, small molecules targeting BRAFV600E have bee...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Jinwoong Kim (लेखक), Byeongha Choi (लेखक), Daseul Im (लेखक), Hoyong Jung (लेखक), Hyungwoo Moon (लेखक), Waqar Aman (लेखक), Jung-Mi Hah (लेखक)
स्वरूप: पुस्तक
प्रकाशित: Taylor & Francis Group, 2019-01-01T00:00:00Z.
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3rd Floor Main Library

होल्डिंग्स विवरण से 3rd Floor Main Library
बोधानक: A1234.567
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