Computer-aided design and synthesis of 3-carbonyl-5-phenyl-1H-pyrazole as highly selective and potent BRAFV600E and CRAF inhibitor
BRAF belongs to the upstream portion of the MAPK pathway, which is involved in cell proliferation and survival. When mutations occur in BRAF, downstream MEK and ERK are phosphorylated irrespective of RAS, resulting in melanoma-like cancer. Over the years, small molecules targeting BRAFV600E have bee...
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स्वरूप: | पुस्तक |
प्रकाशित: |
Taylor & Francis Group,
2019-01-01T00:00:00Z.
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ऑनलाइन पहुंच: | Connect to this object online. |
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Connect to this object online.3rd Floor Main Library
बोधानक: |
A1234.567 |
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प्रति 1 | उपलब्ध |