mGlu2 mechanism-based interventions to treat alcohol relapse

Recently we identified a deficiency in metabotropic glutamate receptor 2 (mGlu2) function in the corticoaccumbal pathway, as a common pathological mechanism underlying alcohol-seeking and relapse behavior. Based on this mechanism, we hypothesized that mGlu2/3 agonists and mGlu2 positive allosteric m...

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Principais autores: Valentina Vengeliene (Autor), Rainer Spanagel (Autor)
Formato: Livro
Publicado em: Frontiers Media S.A., 2022-09-01T00:00:00Z.
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3rd Floor Main Library

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