Reconstructing mutational lineages in breast cancer by multi-patient-targeted single-cell DNA sequencing

• Main Authors: Jake Leighton (Author), Min Hu (Author), Emi Sei (Author), Funda Meric-Bernstam (Author), Nicholas E. Navin (Author)
• Format: Knjiga
• Izdano: Elsevier, 2023-01-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Summary: Single-cell DNA sequencing (scDNA-seq) methods are powerful tools for profiling mutations in cancer cells; however, most genomic regions sequenced in single cells are non-informative. To overcome this issue, we developed a multi-patient-targeted (MPT) scDNA-seq method. MPT involves first pe...