Tolvaptan Attenuates Left Ventricular Fibrosis After Acute Myocardial Infarction in Rats

• Main Authors: Takanori Yamazaki (Author), Yasuhiro Nakamura (Author), Masayuki Shiota (Author), Mayuko Osada-Oka (Author), Hiroyuki Fujiki (Author), Akihisa Hanatani (Author), Kenei Shimada (Author), Katsuyuki Miura (Author), Minoru Yoshiyama (Author), Hiroshi Iwao (Author), Yasukatsu Izumi (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tolvaptan, a non-peptide V2-receptor antagonist, is a newly developed diuretic agent. Recently, we reported that tolvaptan has diuretic as well as anti-inflammatory and anti-fibrotic actions in chronic heart failure. In this study, we investigated whether tolvaptan has a cardioprotective effect in a...