Mitochondrial DNA Hypomethylation Is a Biomarker Associated with Induced Senescence in Human Fetal Heart Mesenchymal Stem Cells

• Main Authors: Dehai Yu (Author), Zhonghua Du (Author), Lingling Pian (Author), Tao Li (Author), Xue Wen (Author), Wei Li (Author), Su-Jeong Kim (Author), Jialin Xiao (Author), Pinchas Cohen (Author), Jiuwei Cui (Author), Andrew R. Hoffman (Author), Ji-Fan Hu (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Fetal heart can regenerate to restore its normal anatomy and function in response to injury, but this regenerative capacity is lost within the first week of postnatal life. Although the specific molecular mechanisms remain to be defined, it is presumed that aging of cardiac stem or proge...