Hepatic stellate cell reprogramming via exosome-mediated CRISPR/dCas9-VP64 delivery

• Main Authors: Nianan Luo (Author), Jiangbin Li (Author), Yafeng Chen (Author), Yan Xu (Author), Yu Wei (Author), Jianguo Lu (Author), Rui Dong (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hepatic stellate cells (HSCs) play a crucial role in the progression of liver fibrosis, which can be considered as the specific therapeutic target of anti-fibrotic treatment. Targeted induction of HSCs to hepatocytes via delivery of clustered regularly interspaced short palindromic repeats (CRISPR)/...