Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging

• Egile Nagusiak: Kristoffer K. Hendel (Egilea), Charlotte Bagger (Egilea), Uffe H. Olesen (Egilea), Christian Janfelt (Egilea), Steen H. Hansen (Egilea), Merete Haedersdal (Egilea), Catharina M. Lerche (Egilea)
• Formatua: Liburua
• Argitaratua: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Bleomycin exhibits antiproliferative effects desirable for use in dermato-oncology but topical use is limited by its 1415 Da molar mass. Ablative fractional laser (AFL)-assisted drug delivery has been shown to enhance drug uptake in skin. The aim of this study was with AFL to deliver bleomycin into...