Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging

• Autori principali: Kristoffer K. Hendel (Autore), Charlotte Bagger (Autore), Uffe H. Olesen (Autore), Christian Janfelt (Autore), Steen H. Hansen (Autore), Merete Haedersdal (Autore), Catharina M. Lerche (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Bleomycin exhibits antiproliferative effects desirable for use in dermato-oncology but topical use is limited by its 1415 Da molar mass. Ablative fractional laser (AFL)-assisted drug delivery has been shown to enhance drug uptake in skin. The aim of this study was with AFL to deliver bleomycin into...