Fractional laser-assisted topical delivery of bleomycin quantified by LC-MS and visualized by MALDI mass spectrometry imaging

• Главные авторы: Kristoffer K. Hendel (Автор), Charlotte Bagger (Автор), Uffe H. Olesen (Автор), Christian Janfelt (Автор), Steen H. Hansen (Автор), Merete Haedersdal (Автор), Catharina M. Lerche (Автор)
• Формат: ‌
• Опубликовано: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Предметы: article
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Bleomycin exhibits antiproliferative effects desirable for use in dermato-oncology but topical use is limited by its 1415 Da molar mass. Ablative fractional laser (AFL)-assisted drug delivery has been shown to enhance drug uptake in skin. The aim of this study was with AFL to deliver bleomycin into...