Population pharmacokinetic modeling of sotatercept in healthy participants and patients with pulmonary arterial hypertension

• Glavni autori: Sihem Ait‐Oudhia (Autor), David Jaworowicz (Autor), Ziheng Hu (Autor), Sébastien Bihorel (Autor), Shuai Hu (Autor), Budda Balasubrahmanyam (Autor), Bipin Mistry (Autor), Janethe deOliveira Pena (Autor), Larissa Wenning (Autor), Ferdous Gheyas (Autor)
• Format: Knjiga
• Izdano: Wiley, 2024-08-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Abstract Sotatercept is a breakthrough, first‐in‐class biologic, that is FDA‐approved for the treatment of pulmonary arterial hypertension (PAH). A population pharmacokinetic (PopPK) model was developed using data from two phase 1 studies in healthy participants, and two phase 2 studies and one phas...