NF-κB/AP-1-Targeted Inhibition of Macrophage-Mediated Inflammatory Responses by Depigmenting Compound AP736 Derived from Natural 1,3-Diphenylpropane Skeleton

• Main Authors: Van Thai Ha (Author), Heung Soo Beak (Author), Eunji Kim (Author), Kwang-Soo Baek (Author), Muhammad Jahangir Hossen (Author), Woo Seok Yang (Author), Yong Kim (Author), Jun Ho Kim (Author), Sungjae Yang (Author), Jeong-Hwan Kim (Author), Yung Hyup Joo (Author), Chang Seok Lee (Author), Joonho Choi (Author), Hong-Ju Shin (Author), Sungyoul Hong (Author), Song Seok Shin (Author), Jae Youl Cho (Author)
• Format: Book
• Published: Hindawi Limited, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AP736 was identified as an antimelanogenic drug that can be used for the prevention of melasma, freckles, and dark spots in skin by acting as a suppressor of melanin synthesis and tyrosinase expression. Since macrophage-mediated inflammatory responses are critical for skin health, here we investigat...