Cryo-Milled β-Glucan Nanoparticles for Oral Drug Delivery

• Main Authors: Guanyu Chen (Author), Yi Liu (Author), Darren Svirskis (Author), Hongyu Li (Author), Man Ying (Author), Weiyue Lu (Author), Jingyuan Wen (Author)
• Format: Book
• Published: MDPI AG, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gemcitabine is a nucleoside analog effective against a number of cancers. However, it has an oral bioavailability of less than 10%, due to its high hydrophilicity and low permeability through the intestinal epithelium. Therefore, the aim of this project was to develop a novel nanoparticulate drug de...