Characterization of P-Glycoprotein Inhibitors for Evaluating the Effect of P-Glycoprotein on the Intestinal Absorption of Drugs

• Main Authors: Yusuke Kono (Author), Iichiro Kawahara (Author), Kohei Shinozaki (Author), Ikuo Nomura (Author), Honoka Marutani (Author), Akira Yamamoto (Author), Takuya Fujita (Author)
• Format: Book
• Published: MDPI AG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

For developing oral drugs, it is necessary to predict the oral absorption of new chemical entities accurately. However, it is difficult because of the involvement of efflux transporters, including P-glycoprotein (P-gp), in their absorption process. In this study, we conducted a comparative analysis...