Diamidines versus Monoamidines as Anti-Pneumocystis Agents: An in Vivo Study

• Main Authors: El-Moukhtar Aliouat (Author), Eduardo Dei-Cas (Author), Anna Martinez (Author), Jean Jacques Vanden Eynde (Author), Sébastien Boutry (Author), Isabelle Mahieu (Author), Delphine Forge (Author), Claire Pinçon (Author), Dimitri Stanicki (Author), Muriel Pottier (Author), Nausicaa Gantois (Author)
• Format: Book
• Published: MDPI AG, 2013-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Some compounds articulated around a piperazine or an ethylenediamine linker have been evaluated in vitro to determine their activity in the presence of a 3T6 fibroblast cell line and an axenic culture of Pneumocystis carinii, respectively. The most efficient antifungal derivatives, namely N,N'-...