Exploring Novel Pyridine Carboxamide Derivatives as Urease Inhibitors: Synthesis, Molecular Docking, Kinetic Studies and ADME Profile

• Hoofdauteurs: Ayesha Naseer (Auteur), Faisal Abdulrhman Osra (Auteur), Asia Naz Awan (Auteur), Aqeel Imran (Auteur), Abdul Hameed (Auteur), Syed Adnan Ali Shah (Auteur), Jamshed Iqbal (Auteur), Zainul Amiruddin Zakaria (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2022-10-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

The rapid development of resistance by ureolytic bacteria which are involved in various life-threatening conditions such as gastric and duodenal cancer has induced the need to develop a new line of therapy which has anti-urease activity. A series of pyridine carboxamide and carbothioamide derivative...