Exploring Novel Pyridine Carboxamide Derivatives as Urease Inhibitors: Synthesis, Molecular Docking, Kinetic Studies and ADME Profile

• Main Authors: Ayesha Naseer (Author), Faisal Abdulrhman Osra (Author), Asia Naz Awan (Author), Aqeel Imran (Author), Abdul Hameed (Author), Syed Adnan Ali Shah (Author), Jamshed Iqbal (Author), Zainul Amiruddin Zakaria (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The rapid development of resistance by ureolytic bacteria which are involved in various life-threatening conditions such as gastric and duodenal cancer has induced the need to develop a new line of therapy which has anti-urease activity. A series of pyridine carboxamide and carbothioamide derivative...