Establishment and Validation of a Rabbit Model for In Vivo Pharmacodynamic Screening of Tachykinin NK2 Antagonists

Establishment and Validation of a Rabbit Model for In Vivo Pharmacodynamic Screening of Tachykinin NK2 Antagonists

We attempted to establish and validate an in vivo pharmacodynamic (PD) rabbit model to screen tachykinin NK2 receptor (NK2-R) antagonists using pharmacological and pharmacokinetic (PK)/PD analyses. Under urethane anesthesia, changes in intracolonic pressure associated with intravenous (i.v.) adminis...

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Main Authors: Takahiro Tanaka (Author), Shiho Matsumoto-Okano (Author), Nobuhiro Inatomi (Author), Yasushi Fujioka (Author), Hidenori Kamiguchi (Author), Masashi Yamaguchi (Author), Akio Imanishi (Author), Makiko Kawamoto (Author), Kasei Miura (Author), Yoichi Nishikawa (Author), Yasuhiro Tsukimi (Author)
Format: Book
Published: Elsevier, 2012-01-01T00:00:00Z.
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