Oral administration of sitagliptin activates CREB and is neuroprotective in murine model of brain trauma

• Main Authors: Brian Dellavalle (Author), Gitte Stokvad Brix (Author), Birgitte Brock (Author), Michael Gejl (Author), Jørgen Rungby (Author), Agnete Larsen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Traumatic brain injury is a major cause of mortality and morbidity. We have previously shown that the injectable glucagon-like peptide-1 (GLP-1) analogue, liraglutide, significantly improved the outcome in mice after severe traumatic brain injury (TBI). In this study we are interested...