Improvement of Nemadectin Production by Overexpressing the Regulatory Gene nemR and Nemadectin Biosynthetic Gene Cluster in Streptomyces Cyaneogriseus

• Main Authors: Yuan-Jie Wu (Author), Song-Bai Yang (Author), Zheng-Yu Zhang (Author), Shao-Xin Chen (Author)
• Format: Bog
• Udgivet: Georg Thieme Verlag KG, 2020-12-01T00:00:00Z.
• Fag: article
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Nemadectin, a 16-member macrocyclic lactone antiparasitic antibiotic, is produced by Streptomyces cyaneogriseus subspecies noncyanogenus. Moxidectin, a C-23 oximate derivative of nemadectin, is widely used as a pesticide due to its broad-spectrum, highly efficient, and safe anthelmintic activity. Ne...