Myocardial Gene Expression of T-bet, GATA-3, Ror-γt, FoxP3, and Hallmark Cytokines in Chronic Chagas Disease Cardiomyopathy: An Essentially Unopposed TH1-Type Response

• Main Authors: Luciana Gabriel Nogueira (Author), Ronaldo Honorato Barros Santos (Author), Alfredo Inácio Fiorelli (Author), Eliane Conti Mairena (Author), Luiz Alberto Benvenuti (Author), Edimar Alcides Bocchi (Author), Noedir Antonio Stolf (Author), Jorge Kalil (Author), Edecio Cunha-Neto (Author)
• Format: Book
• Published: Hindawi Limited, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Chronic Chagas disease cardiomyopathy (CCC), a late consequence of Trypanosoma cruzi infection, is an inflammatory cardiomyopathy with prognosis worse than those of noninflammatory etiology (NIC). Although the T cell-rich myocarditis is known to play a pathogenetic role, the relative con...