The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development.

• Main Authors: Peter D Ziniel (Author), Bhargava Karumudi (Author), Andrew H Barnard (Author), Ethan M S Fisher (Author), Gregory R J Thatcher (Author), Larissa M Podust (Author), David L Williams (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Schistosomiasis affects millions of people in developing countries and is responsible for more than 200,000 deaths annually. Because of toxicity and limited spectrum of activity of alternatives, there is effectively only one drug, praziquantel, available for its treatment. Recent data suggest that d...