Anti-obesity carbonic anhydrase inhibitors: challenges and opportunities
The mitochondrial isoforms VA/VB of metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) are involved in metabolic processes, such as de novo lipogenesis and fatty acid biosynthesis. We review the drug design landscape for obtaining CA VA/VB-selective/effective inhibitors, starting from the clinical ob...
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Taylor & Francis Group,
2022-12-01T00:00:00Z.
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