Long Noncoding RNA-Enriched Vesicles Secreted by Hypoxic Cardiomyocytes Drive Cardiac Fibrosis

• Main Authors: Franziska Kenneweg (Author), Claudia Bang (Author), Ke Xiao (Author), Chantal M. Boulanger (Author), Xavier Loyer (Author), Stephane Mazlan (Author), Blanche Schroen (Author), Steffie Hermans-Beijnsberger (Author), Ariana Foinquinos (Author), Marc N. Hirt (Author), Thomas Eschenhagen (Author), Sandra Funcke (Author), Stevan Stojanovic (Author), Celina Genschel (Author), Katharina Schimmel (Author), Annette Just (Author), Angelika Pfanne (Author), Kristian Scherf (Author), Susann Dehmel (Author), Stella M. Raemon-Buettner (Author), Jan Fiedler (Author), Thomas Thum (Author)
• Format: Book
• Published: Elsevier, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Long non-coding RNAs (lncRNAs) have potential as novel therapeutic targets in cardiovascular diseases, but detailed information about the intercellular lncRNA shuttling mechanisms in the heart is lacking. Here, we report an important novel crosstalk between cardiomyocytes and fibroblasts mediated by...