Amyloidosis, Inflammation, and Oxidative Stress in the Heart of an Alkaptonuric Patient

• Main Authors: Lia Millucci (Author), Lorenzo Ghezzi (Author), Eugenio Paccagnini (Author), Giovanna Giorgetti (Author), Cecilia Viti (Author), Daniela Braconi (Author), Marcella Laschi (Author), Michela Geminiani (Author), Patrizia Soldani (Author), Pietro Lupetti (Author), Maurizio Orlandini (Author), Chiara Benvenuti (Author), Federico Perfetto (Author), Adriano Spreafico (Author), Giulia Bernardini (Author), Annalisa Santucci (Author)
• Format: Book
• Published: Hindawi Limited, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Alkaptonuria, a rare autosomal recessive metabolic disorder caused by deficiency in homogentisate 1,2-dioxygenase activity, leads to accumulation of oxidised homogentisic acid in cartilage and collagenous structures present in all organs and tissues, especially joints and heart, causing...