Intradermal substance P as a challenge agent in healthy individuals

• Main Authors: Wouter tenVoorde (Author), Chika Akinseye (Author), Ismahaan Abdisalaam (Author), Selinde Wind (Author), Naomi Klarenbeek (Author), Menthe Bergmans (Author), Martijn vanDoorn (Author), Robert Rissmann (Author), Rejbinder Kaur (Author), Sarah Hotee (Author), Katie Foster (Author), Arati Nair (Author), Lea Fortunato (Author), Colin Macphee (Author), Sarah Mole (Author), Katrine Baumann (Author), Richard Brigandi (Author)
• Format: Book
• Published: Wiley, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Pharmacological challenge models are deployed to evaluate drug effects during clinical development. Intradermal injection of Substance P (SP) neuropeptide, a potential challenge agent for investigating local mediators, is associated with wheal and flare response mediated by the MRGPRX2 rece...