SCD1 Confers Temozolomide Resistance to Human Glioma Cells via the Akt/GSK3β/β-Catenin Signaling Axis

• Main Authors: Shuang Dai (Author), Yuanliang Yan (Author), Zhijie Xu (Author), Shuangshuang Zeng (Author), Long Qian (Author), Lei Huo (Author), Xuejun Li (Author), Lunquan Sun (Author), Zhicheng Gong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Resistance to temozolomide (TMZ), the standard chemotherapy agent for glioblastoma (GBM), poses a major clinical challenge to GBM prognosis. Understanding the mechanisms of TMZ resistance can help to identify novel drug targets and more effective therapies. Recent studies suggest that bioenergetic a...