Alleviation of cisplatin‐induced hepatotoxicity by gliclazide: Involvement of oxidative stress and caspase‐3 activity

• Main Authors: Fatemeh Taghizadeh (Author), Seyed Jalal Hosseinimehr (Author), Mehryar Zargari (Author), Abbasali Karimpour Malekshah (Author), Mansoureh Mirzaei (Author), Fereshteh Talebpour Amiri (Author)
• Format: Book
• Published: Wiley, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Aims Cisplatin (CP), as an effective alkylating agent, is widely used in cancer treatment, while hepatotoxicity is one of its side effects. Gliclazide (GLZ), as an oral hypoglycemic drug, has antioxidant and anti‐inflammatory properties. This study was designed to investigate the protective...