IL-6 Inhibition Reduces STAT3 Activation and Enhances the Antitumor Effect of Carboplatin

• Autores principales: Zhi-Yong Wang (Autor), Jun-Ai Zhang (Autor), Xian-Jin Wu (Autor), Yan-Fang Liang (Autor), Yuan-Bin Lu (Autor), Yu-Chi Gao (Autor), You-Chao Dai (Autor), Shi-Yan Yu (Autor), Yan Jia (Autor), Xiao-Xia Fu (Autor), Xiaoquan Rao (Autor), Jun-Fa Xu (Autor), Jixin Zhong (Autor)
• Formato: Libro
• Publicado: Hindawi Limited, 2016-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Recent studies suggest that tumor-associated macrophage-produced IL-6 is an important mediator within the tumor microenvironment that promotes tumor growth. The activation of IL-6/STAT3 axis has been associated with chemoresistance and poor prognosis of a variety of cancers including colorectal carc...