IL-6 Inhibition Reduces STAT3 Activation and Enhances the Antitumor Effect of Carboplatin

• Main Authors: Zhi-Yong Wang (Author), Jun-Ai Zhang (Author), Xian-Jin Wu (Author), Yan-Fang Liang (Author), Yuan-Bin Lu (Author), Yu-Chi Gao (Author), You-Chao Dai (Author), Shi-Yan Yu (Author), Yan Jia (Author), Xiao-Xia Fu (Author), Xiaoquan Rao (Author), Jun-Fa Xu (Author), Jixin Zhong (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent studies suggest that tumor-associated macrophage-produced IL-6 is an important mediator within the tumor microenvironment that promotes tumor growth. The activation of IL-6/STAT3 axis has been associated with chemoresistance and poor prognosis of a variety of cancers including colorectal carc...