Levodopa/Benserazide PLGA Microsphere Prevents L-Dopa-Induced Dyskinesia via Lower β-Arrestin2 in 6-Hydroxydopamine Parkinson's Rats

• Egile Nagusiak: Wen-Wen Wang (Egilea), Xing-Ru Zhang (Egilea), Jing-Ya Lin (Egilea), Zeng-Rui Zhang (Egilea), Zhen Wang (Egilea), Si-Yan Chen (Egilea), Cheng-Long Xie (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2019-06-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Prolonged pulsatile administration of Levodopa (L-dopa) can generate L-dopa-induced dyskinesia (LID). Numerous research has reported that continuous dopamine delivery (CDD) was useful in reducing the severity of LID. 6-OHDA lesioned rats were divided into two groups to receive intermittent L-dopa st...