Population pharmacokinetic analysis of dupilumab in adult and adolescent patients with asthma

• Main Authors: Li Zhang (Author), Yue Gao (Author), Meng Li (Author), Christine Xu (Author), John D. Davis (Author), Vanaja Kanamaluru (Author), Qiang Lu (Author)
• Format: Book
• Published: Wiley, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract A population pharmacokinetic model was developed using data from healthy subjects and patients with moderate‐to‐severe asthma receiving intravenous or subcutaneous dupilumab doses. A total of nine phase I to phase III studies were pooled (202 healthy subjects and 1912 patients with asthma i...