Cigarette Smoke Reduces Fatty Acid Catabolism, Leading to Apoptosis in Lung Endothelial Cells: Implication for Pathogenesis of COPD

• Main Authors: Jiannan Gong (Author), Hui Zhao (Author), Tanzhen Liu (Author), Lifang Li (Author), Erjing Cheng (Author), Shuyin Zhi (Author), Lufei Kong (Author), Hong-Wei Yao (Author), Jianqiang Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Endothelial cell (EC) apoptosis contributes to cigarette smoke (CS)-induced pulmonary emphysema. Metabolism of glucose, glutamine, and fatty acid is dysregulated in patients with chronic obstructive pulmonary disease (COPD). Whether CS causes metabolic dysregulation in ECs leading to development of...