HIV Env conserved element DNA vaccine alters immunodominance in macaques

• Main Authors: Xintao Hu (Author), Antonio Valentin (Author), Margherita Rosati (Author), Siriphan Manocheewa (Author), Candido Alicea (Author), Bhabadeb Chowdhury (Author), Jenifer Bear (Author), Kate E. Broderick (Author), Niranjan Y. Sardesai (Author), Sylvie Le Gall (Author), James I. Mullins (Author), George N. Pavlakis (Author), Barbara K. Felber (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Sequence diversity and immunodominance are major obstacles in the design of an effective vaccine against HIV. HIV Env is a highly-glycosylated protein composed of 'conserved' and 'variable' regions. The latter contains immunodominant epitopes that are frequently targeted by the i...