Association of Single Nucleotide Polymorphisms in the IL-18 Gene with Production of IL-18 Protein by Mononuclear Cells from Healthy Donors

• Main Authors: Khripko Olga Pavlovna (Author), Sennikova Nadegda Sergeevna (Author), Lopatnikova Julia Anatolievna (Author), Khripko Jurii Ivanovich (Author), Filipenko Maxim Leonidovich (Author), Khrapov Evgenii Alexandrovich (Author), Gelfgat Evgenii L'vovich (Author), Yakushenko Elena Vladimirovna (Author), Kozlov Vladimir Alexandrovich (Author), Sennikov Sergei Vitalievich (Author)
• Format: Book
• Published: Hindawi Limited, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IL-18 has proinflammatory effects and participates in both innate and adaptive cellular and humoral immunity. A number of SNPs that influence IL-18 production are found in the gene promoter region. We investigated the association of SNPs in the IL-18 promoter at −607 and −137 with the level of IL-18...