PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs

• Главные авторы: Bruno M.D.C. Godinho (Автор), Emily G. Knox (Автор), Samuel Hildebrand (Автор), James W. Gilbert (Автор), Dimas Echeverria (Автор), Zachary Kennedy (Автор), Reka A. Haraszti (Автор), Chantal M. Ferguson (Автор), Andrew H. Coles (Автор), Annabelle Biscans (Автор), Jillian Caiazzi (Автор), Julia F. Alterman (Автор), Matthew R. Hassler (Автор), Anastasia Khvorova (Автор)
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• Опубликовано: Elsevier, 2022-09-01T00:00:00Z.
• Предметы: article
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Effective systemic delivery of small interfering RNAs (siRNAs) to tissues other than liver remains a challenge. siRNAs are small (∼15 kDa) and therefore rapidly cleared by the kidneys, resulting in limited blood residence times and tissue exposure. Current strategies to improve the unfavorable pharm...