Separation and simultaneous quantitation of PGF2α and its epimer 8-iso-PGF2α using modifier-assisted differential mobility spectrometry tandem mass spectrometry

• Main Authors: Chunsu Liang (Author), Hui Sun (Author), Xiangjun Meng (Author), Lei Yin (Author), J. Paul Fawcett (Author), Huaidong Yu (Author), Ting Liu (Author), Jingkai Gu (Author)
• Format: Book
• Published: Elsevier, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Because many therapeutic agents are contaminated by epimeric impurities or form epimers as a result of metabolism, analytical tools capable of determining epimers are increasingly in demand. This article is a proof-of-principle report of a novel DMS-MS/MS method to separate and simultaneously quanti...