Evaluation of a flavonoids library for inhibition of pancreatic α-amylase towards a structure-activity relationship

• Main Authors: Carina Proença (Author), Marisa Freitas (Author), Daniela Ribeiro (Author), Sara M. Tomé (Author), Eduardo F. T. Oliveira (Author), Matilde F. Viegas (Author), Alberto N. Araújo (Author), Maria J. Ramos (Author), Artur M. S. Silva (Author), Pedro A. Fernandes (Author), Eduarda Fernandes (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

α-Amylase has been considered an important therapeutic target for the management of type 2 diabetes mellitus (T2DM), decreasing postprandial hyperglycaemia (PPHG). In the present work, a panel of 40 structurally related flavonoids was tested, concerning their ability to inhibit α-amylase activity, u...