Nose-to-brain delivery of temozolomide-loaded PLGA nanoparticles functionalized with anti-EPHA3 for glioblastoma targeting

• Main Authors: Liuxiang Chu (Author), Aiping Wang (Author), Ling Ni (Author), Xiuju Yan (Author), Yina Song (Author), Mingyu Zhao (Author), Kaoxiang Sun (Author), Hongjie Mu (Author), Sha Liu (Author), Zimei Wu (Author), Chunyan Zhang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glioblastoma is the most common malignant brain tumor. Efficient delivery of drugs targeting glioblastomas remains a challenge. Ephrin type-A receptor 3 (EPHA3) tyrosine kinase antibody-modified polylactide-co-glycolide (PLGA) nanoparticles (NPs) were developed to target glioblastoma via nose-to-bra...