Affibody-Derived Drug Conjugates Targeting HER2: Effect of Drug Load on Cytotoxicity and Biodistribution

• Main Authors: Haozhong Ding (Author), Tianqi Xu (Author), Jie Zhang (Author), Vladimir Tolmachev (Author), Maryam Oroujeni (Author), Anna Orlova (Author), Torbjörn Gräslund (Author), Anzhelika Vorobyeva (Author)
• Format: Book
• Published: MDPI AG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Affibody molecules hold great promise as carriers of cytotoxic drugs for cancer therapy due to their typically high affinity, easy production, and inherent control of the drug molecules' loading and spatial arrangement. Here, the impact of increasing the drug load from one to three on the prope...