Intracolonic Mustard Oil Induces Visceral Pain in Mice by TRPA1-Dependent and -Independent Mechanisms: Role of Tissue Injury and P2X Receptors

• Автори: Rafael Gonzalez-Cano (Автор), Ángeles Montilla-García (Автор), Gloria Perazzoli (Автор), Jesús M. Torres (Автор), Francisco J. Cañizares (Автор), Eduardo Fernández-Segura (Автор), Michael Costigan (Автор), José M. Baeyens (Автор), Enrique J. Cobos (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Both TRPA1 and purinergic P2X receptors have been proposed as potential targets for the treatment of visceral pain. We found that the intracolonic administration of a low dose mustard oil (0.5%), a well-known TRPA1 agonist, produced nociceptive responses and abdominal wall referred mechanical hypera...