Intracolonic Mustard Oil Induces Visceral Pain in Mice by TRPA1-Dependent and -Independent Mechanisms: Role of Tissue Injury and P2X Receptors

• Main Authors: Rafael Gonzalez-Cano (Author), Ángeles Montilla-García (Author), Gloria Perazzoli (Author), Jesús M. Torres (Author), Francisco J. Cañizares (Author), Eduardo Fernández-Segura (Author), Michael Costigan (Author), José M. Baeyens (Author), Enrique J. Cobos (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Both TRPA1 and purinergic P2X receptors have been proposed as potential targets for the treatment of visceral pain. We found that the intracolonic administration of a low dose mustard oil (0.5%), a well-known TRPA1 agonist, produced nociceptive responses and abdominal wall referred mechanical hypera...