CDK12 inhibition upregulates ATG7 triggering autophagy via AKT/FOXO3 pathway and enhances anti-PD-1 efficacy in colorectal cancer

• Main Authors: Zimei Wu (Author), Wenxin Zhang (Author), Lu Chen (Author), Tianxiao Wang (Author), Xinhai Wang (Author), Huanying Shi (Author), Liudi Zhang (Author), Mingkang Zhong (Author), Xiaojin Shi (Author), Xiang Mao (Author), Haifei Chen (Author), Qunyi Li (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As the world's fourth most deadly cancer, colorectal cancer (CRC) still needed the novel therapeutic drugs and target urgently. Although cyclin-dependent kinase 12 (CDK12) has been shown to be implicated in the malignancy of several types of cancer, its functional role and mechanism in CRC rema...