Chitosan/Cyclodextrin Nanospheres for Potential Nose-to-Brain Targeting of Idebenone

• Main Authors: Federica De Gaetano (Author), Nicola d'Avanzo (Author), Antonia Mancuso (Author), Anna De Gaetano (Author), Giuseppe Paladini (Author), Francesco Caridi (Author), Valentina Venuti (Author), Donatella Paolino (Author), Cinzia Anna Ventura (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Idebenone (IDE) is a powerful antioxidant that is potentially active towards cerebral diseases, but its low water solubility and fast first pass metabolism reduce its accumulation in the brain, making it ineffective. In this work, we developed cyclodextrin-based chitosan nanospheres (CS NPs) as pote...