Global Sensitivity Analysis of Ventricular Myocyte Model-Derived Metrics for Proarrhythmic Risk Assessment

• المؤلفون الرئيسيون: Jaimit Parikh (مؤلف), Paolo Di Achille (مؤلف), James Kozloski (مؤلف), Viatcheslav Gurev (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2019-10-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Multiscale computational models of the heart are being extensively investigated for improved assessment of drug-induced torsades de pointes (TdP) risk, a fatal side effect of many drugs. Model-derived metrics such as action potential duration and net charge carried by ionic currents (qNet) have been...