A next-generation Fab library platform directly yielding drug-like antibodies with high affinity, diversity, and developability

• প্রধান লেখক: Fortunato Ferrara (লেখক), Adeline Fanni (লেখক), Andre A. R. Teixeira (লেখক), Esteban Molina (লেখক), Camila Leal-Lopes (লেখক), Ashley DeAguero (লেখক), Sara D'Angelo (লেখক), M. Frank Erasmus (লেখক), Laura Spector (লেখক), Luis Antonio Rodriguez Carnero (লেখক), Jianquan Li (লেখক), Thomas J. Pohl (লেখক), Nikolai Suslov (লেখক), Klervi Desrumeaux (লেখক), Conor McMahon (লেখক), Sagar Kathuria (লেখক), Andrew R. M. Bradbury (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

We previously described an in vitro single-chain fragment (scFv) library platform originally designed to generate antibodies with excellent developability properties. The platform design was based on the use of clinical antibodies as scaffolds into which replicated natural complementarity-determinin...