A next-generation Fab library platform directly yielding drug-like antibodies with high affinity, diversity, and developability

• Main Authors: Fortunato Ferrara (Author), Adeline Fanni (Author), Andre A. R. Teixeira (Author), Esteban Molina (Author), Camila Leal-Lopes (Author), Ashley DeAguero (Author), Sara D'Angelo (Author), M. Frank Erasmus (Author), Laura Spector (Author), Luis Antonio Rodriguez Carnero (Author), Jianquan Li (Author), Thomas J. Pohl (Author), Nikolai Suslov (Author), Klervi Desrumeaux (Author), Conor McMahon (Author), Sagar Kathuria (Author), Andrew R. M. Bradbury (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously described an in vitro single-chain fragment (scFv) library platform originally designed to generate antibodies with excellent developability properties. The platform design was based on the use of clinical antibodies as scaffolds into which replicated natural complementarity-determinin...