Celastrol inhibits chondrosarcoma proliferation, migration and invasion through suppression CIP2A/c-MYC signaling pathway

• Main Authors: Jinhui Wu (Author), Muchen Ding (Author), Ningfang Mao (Author), Yungang Wu (Author), Chao Wang (Author), Jiabin Yuan (Author), Xiong Miao (Author), Jingfeng Li (Author), Zhicai Shi (Author)
• Format: Book
• Published: Elsevier, 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chondrosarcomas (CS) is the second most frequent tumors of cartilage origin. A small compound extracted from Thunder God Vine (Tripterygium wilfordii Hook. F.) called celastrol can directly bound CIP2A protein and effectively inhibit cell proliferation and induce apoptosis in several cancer cells. H...