Poly(pseudo)rotaxanes formed by mixed micelles and α-cyclodextrin enhance terbinafine nail permeation to deeper layers

• Egile Nagusiak: Anna Paula Krawczyk-Santos (Egilea), Ricardo Neves Marreto (Egilea), Angel Concheiro (Egilea), Carmen Alvarez-Lorenzo (Egilea), Stephânia Fleury Taveira (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2022-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

This work aimed to develop water-based formulations for onychomycosis topical treatment using micelles of small pegylated surfactants associated with α-cyclodextrin (αCD) to deliver terbinafine to the nail. Kolliphor® RH40 (RH40) and Gelucire® 48/16 (GEL) single and mixed micelles (RH40:GEL 1:1) wer...