Dose optimization of cefazolin in South African children undergoing cardiac surgery with cardiopulmonary bypass

• Main Authors: Manna Semere Gebreyesus (Author), Alexandra Dresner (Author), Lubbe Wiesner (Author), Ettienne Coetzee (Author), Tess Verschuuren (Author), Roeland Wasmann (Author), Paolo Denti (Author)
• Format: Book
• Published: Wiley, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Cefazolin is an antibiotic used to prevent surgical site infections. During cardiac surgery with cardiopulmonary bypass (CPB), its efficacy target could be underachieved. We aimed to develop a population pharmacokinetic model for cefazolin in children and optimize the prophylactic dosing re...