Acacetin protects against depression-associated dry eye disease by regulating ubiquitination of NLRP3 through gp78 signal

• Main Authors: Mingxia Xie (Author), Hanqing Wang (Author), Jun Peng (Author), Dongqin Qing (Author), Xi Zhang (Author), Dongwei Guo (Author), Pan Meng (Author), Zhihong Luo (Author), Xiaoye Wang (Author), Qinghua Peng (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dry eye disease (DED) is a multifactorial syndrome that commonly occurs with depression. However, therapies targeting depression-related dry eye disease are rare. In the current study, we studied the beneficial effect of a natural flavone, acacetin, in depression-associated dry eye disease by utiliz...