In Vitro Metabolism of Donepezil in Liver Microsomes Using Non-Targeted Metabolomics

• Autori principali: Sin-Eun Kim (Autore), Hyung-Ju Seo (Autore), Yeojin Jeong (Autore), Gyung-Min Lee (Autore), Seung-Bae Ji (Autore), So-Young Park (Autore), Zhexue Wu (Autore), Sangkyu Lee (Autore), Sunghwan Kim (Autore), Kwang-Hyeon Liu (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2021-06-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Donepezil is a reversible acetylcholinesterase inhibitor that is currently the most commonly prescribed drug for the treatment of Alzheimer's disease. In general, donepezil is known as a safe and well-tolerated drug, and it was not associated with liver abnormalities in several clinical trials....