In Vitro Metabolism of Donepezil in Liver Microsomes Using Non-Targeted Metabolomics

• Main Authors: Sin-Eun Kim (Author), Hyung-Ju Seo (Author), Yeojin Jeong (Author), Gyung-Min Lee (Author), Seung-Bae Ji (Author), So-Young Park (Author), Zhexue Wu (Author), Sangkyu Lee (Author), Sunghwan Kim (Author), Kwang-Hyeon Liu (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Donepezil is a reversible acetylcholinesterase inhibitor that is currently the most commonly prescribed drug for the treatment of Alzheimer's disease. In general, donepezil is known as a safe and well-tolerated drug, and it was not associated with liver abnormalities in several clinical trials....