The Role of Human Aldo-Keto Reductases (AKRs) in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH-catechols and PAH o-Quinones

• Main Authors: Li eZhang (Author), Yi eJin (Author), Meng eHuang (Author), Trevor M. Penning (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Polycyclic aromatic hydrocarbons (PAH) are ubiquitous environmental pollutants. They are procarcinogens requiring metabolic activation to elicit their deleterious effects. Aldo-keto reductases (AKR) catalyze the oxidation of proximate carcinogenic PAH trans-dihydrodiols to yield electrophilic and re...