Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis, in vitro assays, and in silico studies

• Main Authors: Mohamed H. Saad (Author), Tarek F. El-Moselhy (Author), Nabaweya S, El-Din (Author), Ahmed B. M. Mehany (Author), Amany Belal (Author), Mohammed A. S. Abourehab (Author), Haytham O. Tawfik (Author), Mervat H. El-Hamamsy (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Two new series of symmetric (1a-h) and asymmetric (2a-l) 1,4-DHP derivatives were designed, synthesised, and evaluated as anticancer agents. In vitro anticancer screening of target compounds via National cancer institute "NCI" revealed that analogues 1g, 2e, and 2l demonstrated antiprolife...